Drug interactions
Daridorexant + Zolpidem
Severity: Moderate
Daridorexant and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sleep-promoting drugs, and together they increase sedation and the risk of next-day psychomotor and cognitive impairment. This raises the risk of falls and accidents.
What this interaction means in plain words
Daridorexant and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and orexin receptor antagonism.
What to do
Avoid using two hypnotics together; if unavoidable, use the lowest doses and counsel on next-day impairment, particularly driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Zolpidem?
MediHelp rates the interaction as moderate. Daridorexant and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sleep-promoting drugs, and together they increase sedation and the risk of next-day psychomotor and cognitive impairment. This raises the risk of falls and accidents.
How serious is the interaction between Daridorexant and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two hypnotics together; if unavoidable, use the lowest doses and counsel on next-day impairment, particularly driving.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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