Drug interactions
Darifenacin + Dasatinib
Severity: Minor
Darifenacin and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a CYP3A4 substrate and a weak time-dependent inhibitor of it, so it could slightly raise darifenacin levels. Darifenacin is not a meaningful CYP3A4 inhibitor, so any effect on dasatinib is unlikely. The clinical significance is probably small.
What this interaction means in plain words
Darifenacin and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Dasatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by dasatinib may reduce darifenacin metabolism.
What to do
No routine adjustment is needed. Monitor for anticholinergic adverse effects of darifenacin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Darifenacin with Dasatinib?
MediHelp rates the interaction as minor. Darifenacin and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a CYP3A4 substrate and a weak time-dependent inhibitor of it, so it could slightly raise darifenacin levels. Darifenacin is not a meaningful CYP3A4 inhibitor, so any effect on dasatinib is unlikely. The clinical significance is probably small.
How serious is the interaction between Darifenacin and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for anticholinergic adverse effects of darifenacin.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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