Drug interactions
Darifenacin + Dronedarone
Severity: Moderate
Darifenacin and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is both a CYP3A4 substrate and a moderate CYP3A4 and a CYP2D6 inhibitor, and darifenacin is mainly a substrate of these enzymes. Darifenacin exposure may rise, and dronedarone exposure may be affected only minimally. The clinical significance is chiefly increased anticholinergic effects.
What this interaction means in plain words
Darifenacin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP2D6 and CYP3A4 and may raise darifenacin levels; darifenacin is a weak CYP2D6 inhibitor with little effect on dronedarone.
What to do
Monitor for anticholinergic effects and limit darifenacin to 7.5 mg daily if they occur. Check the ECG for QT changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Darifenacin with Dronedarone?
MediHelp rates the interaction as moderate. Darifenacin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is both a CYP3A4 substrate and a moderate CYP3A4 and a CYP2D6 inhibitor, and darifenacin is mainly a substrate of these enzymes. Darifenacin exposure may rise, and dronedarone exposure may be affected only minimally. The clinical significance is chiefly increased anticholinergic effects.
How serious is the interaction between Darifenacin and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and limit darifenacin to 7.5 mg daily if they occur. Check the ECG for QT changes.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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