Drug interactions
Darifenacin + Eliglustat
Severity: Moderate
Darifenacin and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a CYP2D6 substrate with only weak CYP2D6 inhibition, while eliglustat is metabolized by CYP2D6 and CYP3A. Darifenacin is not a strong or moderate CYP2D6 inhibitor, so a major rise in eliglustat exposure is not expected. Additionally, eliglustat can inhibit CYP2D6 and P-gp and could modestly raise darifenacin levels, so the true effect is likely small.
What this interaction means in plain words
Darifenacin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Eliglustat belongs to Miscellaneous.
Why it happens
Possible modest competition at CYP2D6; eliglustat may inhibit CYP2D6 and increase darifenacin exposure.
What to do
Monitor for anticholinergic effects of darifenacin such as dry mouth and constipation, and for eliglustat adverse effects including QT-related symptoms. Check the patient's CYP2D6 genotype and other interacting drugs before use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Darifenacin with Eliglustat?
MediHelp rates the interaction as moderate. Darifenacin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darifenacin is a CYP2D6 substrate with only weak CYP2D6 inhibition, while eliglustat is metabolized by CYP2D6 and CYP3A. Darifenacin is not a strong or moderate CYP2D6 inhibitor, so a major rise in eliglustat exposure is not expected. Additionally, eliglustat can inhibit CYP2D6 and P-gp and could modestly raise darifenacin levels, so the true effect is likely small.
How serious is the interaction between Darifenacin and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects of darifenacin such as dry mouth and constipation, and for eliglustat adverse effects including QT-related symptoms. Check the patient's CYP2D6 genotype and other interacting drugs before use.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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