Drug interactions
Darifenacin + Flibanserin
Severity: Minor
Darifenacin and Flibanserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a CYP3A4 and CYP2D6 substrate, not a CYP3A4 inhibitor, so it is unlikely to raise flibanserin levels. Flibanserin is a weak P-gp inhibitor and may slightly affect darifenacin. A clinically important interaction is unlikely.
What this interaction means in plain words
Darifenacin and Flibanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Flibanserin belongs to Genitourinary.
Why it happens
No established mechanism; theoretical minor transporter or enzyme effects.
What to do
No adjustment is needed. Monitor for dizziness and anticholinergic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Flibanserin?
MediHelp rates the interaction as minor. Darifenacin and Flibanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a CYP3A4 and CYP2D6 substrate, not a CYP3A4 inhibitor, so it is unlikely to raise flibanserin levels. Flibanserin is a weak P-gp inhibitor and may slightly affect darifenacin. A clinically important interaction is unlikely.
How serious is the interaction between Darifenacin and Flibanserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor for dizziness and anticholinergic effects.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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