Drug interactions
Darifenacin + Fluconazole
Severity: Moderate
Darifenacin and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and can raise darifenacin exposure, increasing antimuscarinic adverse effects such as dry mouth, constipation and blurred vision. The effect is generally smaller than with potent inhibitors such as ketoconazole.
What this interaction means in plain words
Darifenacin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated darifenacin metabolism by fluconazole.
What to do
Monitor for anticholinergic effects during co-administration. Keep darifenacin at 7.5 mg daily if tolerability problems arise, or consider an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darifenacin and Fluconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Darifenacin
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Darifenacin with Fluconazole?
MediHelp rates the interaction as moderate. Darifenacin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP3A4 inhibitor and can raise darifenacin exposure, increasing antimuscarinic adverse effects such as dry mouth, constipation and blurred vision. The effect is generally smaller than with potent inhibitors such as ketoconazole.
How serious is the interaction between Darifenacin and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects during co-administration. Keep darifenacin at 7.5 mg daily if tolerability problems arise, or consider an alternative agent.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
