Drug interactions
Darifenacin + Fluphenazine
Severity: Moderate
Darifenacin and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has anticholinergic properties, so adding darifenacin increases the risk of dry mouth, constipation, urinary retention, confusion and heat intolerance. Darifenacin's CYP2D6 inhibition may also modestly raise phenothiazine levels.
What this interaction means in plain words
Darifenacin and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, with possible minor CYP2D6 inhibition by darifenacin.
What to do
Monitor for anticholinergic adverse effects, particularly in elderly patients. Consider a non-anticholinergic bladder treatment if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Darifenacin with Fluphenazine?
MediHelp rates the interaction as moderate. Darifenacin and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has anticholinergic properties, so adding darifenacin increases the risk of dry mouth, constipation, urinary retention, confusion and heat intolerance. Darifenacin's CYP2D6 inhibition may also modestly raise phenothiazine levels.
How serious is the interaction between Darifenacin and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in elderly patients. Consider a non-anticholinergic bladder treatment if symptoms develop.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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