Drug interactions
Darifenacin + Fluvoxamine
Severity: Moderate
Darifenacin and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP3A4 (modestly) and CYP1A2 and CYP2C19 more strongly, and can raise darifenacin concentrations, increasing antimuscarinic adverse effects. The clinical effect is usually modest.
What this interaction means in plain words
Darifenacin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated darifenacin metabolism by fluvoxamine.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention. Limit darifenacin to the lower dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Darifenacin with Fluvoxamine?
MediHelp rates the interaction as moderate. Darifenacin and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP3A4 (modestly) and CYP1A2 and CYP2C19 more strongly, and can raise darifenacin concentrations, increasing antimuscarinic adverse effects. The clinical effect is usually modest.
How serious is the interaction between Darifenacin and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention. Limit darifenacin to the lower dose if these occur.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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