Drug interactions
Darifenacin + Glycopyrronium
Severity: Moderate
Darifenacin and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic drugs, so use together increases the likelihood of dry mouth, constipation, blurred vision, tachycardia and urinary retention. The therapeutic benefit of combining them is generally small.
What this interaction means in plain words
Darifenacin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Glycopyrronium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid concurrent use of two antimuscarinics when possible; if combined, monitor for anticholinergic effects and post-void residual urine in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Glycopyrronium?
MediHelp rates the interaction as moderate. Darifenacin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic drugs, so use together increases the likelihood of dry mouth, constipation, blurred vision, tachycardia and urinary retention. The therapeutic benefit of combining them is generally small.
How serious is the interaction between Darifenacin and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antimuscarinics when possible; if combined, monitor for anticholinergic effects and post-void residual urine in at-risk patients.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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