Drug interactions
Darifenacin + Haloperidol
Severity: Moderate
Darifenacin and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol has some anticholinergic activity and is partly metabolised by CYP2D6, which darifenacin inhibits. The combination may increase anticholinergic adverse effects and modestly raise haloperidol exposure, with QT prolongation risk.
What this interaction means in plain words
Darifenacin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Haloperidol belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, plus CYP2D6 inhibition by darifenacin.
What to do
Monitor for anticholinergic effects, extrapyramidal symptoms and QT prolongation. Reduce the haloperidol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Darifenacin with Haloperidol?
MediHelp rates the interaction as moderate. Darifenacin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol has some anticholinergic activity and is partly metabolised by CYP2D6, which darifenacin inhibits. The combination may increase anticholinergic adverse effects and modestly raise haloperidol exposure, with QT prolongation risk.
How serious is the interaction between Darifenacin and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, extrapyramidal symptoms and QT prolongation. Reduce the haloperidol dose if adverse effects appear.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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