Drug interactions
Darifenacin + Iloperidone
Severity: Moderate
Darifenacin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin inhibits CYP2D6 and CYP3A4 to some degree, which may raise iloperidone levels and its QT-prolonging potential. Additive anticholinergic effects may also occur.
What this interaction means in plain words
Darifenacin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Iloperidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and CYP3A4 by darifenacin increases iloperidone exposure, with additive antimuscarinic effects.
What to do
Monitor for sedation, orthostasis, anticholinergic effects and QT prolongation, especially with other QT-prolonging drugs or CYP inhibitors. Consider ECG monitoring in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Darifenacin with Iloperidone?
MediHelp rates the interaction as moderate. Darifenacin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darifenacin inhibits CYP2D6 and CYP3A4 to some degree, which may raise iloperidone levels and its QT-prolonging potential. Additive anticholinergic effects may also occur.
How serious is the interaction between Darifenacin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis, anticholinergic effects and QT prolongation, especially with other QT-prolonging drugs or CYP inhibitors. Consider ECG monitoring in high-risk patients.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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