Drug interactions
Darifenacin + Itraconazole
Severity: Major
Darifenacin and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and markedly increases darifenacin exposure. This heightens the risk of anticholinergic toxicity.
What this interaction means in plain words
Darifenacin and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darifenacin belongs to Genitourinary; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by itraconazole decreases darifenacin clearance.
What to do
Avoid the combination where possible, or cap darifenacin at 7.5 mg daily with close monitoring for anticholinergic effects. The inhibition can persist for some time after itraconazole stops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Darifenacin
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Darifenacin with Itraconazole?
MediHelp rates the interaction as major. Darifenacin and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole is a strong CYP3A4 inhibitor and markedly increases darifenacin exposure. This heightens the risk of anticholinergic toxicity.
How serious is the interaction between Darifenacin and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or cap darifenacin at 7.5 mg daily with close monitoring for anticholinergic effects. The inhibition can persist for some time after itraconazole stops.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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