Drug interactions
Darifenacin + Lomitapide
Severity: Moderate
Darifenacin and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate and exposure can increase with CYP3A4 inhibitors. Darifenacin is a weak inhibitor, so the effect is likely modest but may add to the risk of hepatotoxicity and gastrointestinal effects.
What this interaction means in plain words
Darifenacin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated lomitapide metabolism.
What to do
Monitor liver enzymes and gastrointestinal tolerance, and keep lomitapide at or below the labeled maximum dose with weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Darifenacin with Lomitapide?
MediHelp rates the interaction as moderate. Darifenacin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a sensitive CYP3A4 substrate and exposure can increase with CYP3A4 inhibitors. Darifenacin is a weak inhibitor, so the effect is likely modest but may add to the risk of hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Darifenacin and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerance, and keep lomitapide at or below the labeled maximum dose with weak CYP3A4 inhibitors.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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