Drug interactions
Darifenacin + Metoprolol
Severity: Moderate
Darifenacin and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol is a CYP2D6 substrate, and darifenacin has been shown to increase its exposure modestly. This may lead to greater bradycardia or hypotension, though the effect is usually small.
What this interaction means in plain words
Darifenacin and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Metoprolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated metoprolol metabolism by darifenacin.
What to do
Monitor heart rate and blood pressure after starting darifenacin. Reduce the metoprolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Darifenacin with Metoprolol?
MediHelp rates the interaction as moderate. Darifenacin and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol is a CYP2D6 substrate, and darifenacin has been shown to increase its exposure modestly. This may lead to greater bradycardia or hypotension, though the effect is usually small.
How serious is the interaction between Darifenacin and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting darifenacin. Reduce the metoprolol dose if bradycardia or hypotension develops.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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