Drug interactions
Darifenacin + Midazolam
Severity: Minor
Darifenacin and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin has been reported to produce a small increase in midazolam exposure, which is not usually clinically important. Sedation may occasionally be a little greater.
What this interaction means in plain words
Darifenacin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Midazolam belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by darifenacin modestly reduces midazolam clearance.
What to do
No dose change is generally needed; monitor sedation as usual with midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Darifenacin with Midazolam?
MediHelp rates the interaction as minor. Darifenacin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin has been reported to produce a small increase in midazolam exposure, which is not usually clinically important. Sedation may occasionally be a little greater.
How serious is the interaction between Darifenacin and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor sedation as usual with midazolam.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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