Drug interactions
Darifenacin + Nisoldipine
Severity: Minor
Darifenacin and Nisoldipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a weak CYP3A4 inhibitor and could slightly increase nisoldipine exposure. This may enhance blood pressure lowering, flushing, or edema.
What this interaction means in plain words
Darifenacin and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Nisoldipine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated nisoldipine metabolism by darifenacin.
What to do
Usually no dose change is required; monitor blood pressure and for peripheral edema when starting darifenacin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Darifenacin with Nisoldipine?
MediHelp rates the interaction as minor. Darifenacin and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a weak CYP3A4 inhibitor and could slightly increase nisoldipine exposure. This may enhance blood pressure lowering, flushing, or edema.
How serious is the interaction between Darifenacin and Nisoldipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is required; monitor blood pressure and for peripheral edema when starting darifenacin.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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