Drug interactions
Darifenacin + Ribociclib
Severity: Moderate
Darifenacin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and may raise darifenacin concentrations, increasing anticholinergic effects. Both drugs may also affect the QT interval to some degree.
What this interaction means in plain words
Darifenacin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib reduces darifenacin clearance.
What to do
Monitor for anticholinergic effects and limit darifenacin to 7.5 mg daily if they occur. Monitor the ECG as required for ribociclib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Darifenacin with Ribociclib?
MediHelp rates the interaction as moderate. Darifenacin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a CYP3A4 inhibitor and may raise darifenacin concentrations, increasing anticholinergic effects. Both drugs may also affect the QT interval to some degree.
How serious is the interaction between Darifenacin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and limit darifenacin to 7.5 mg daily if they occur. Monitor the ECG as required for ribociclib.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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