Drug interactions
Darifenacin + Tacrolimus
Severity: Minor
Darifenacin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is mainly a CYP3A4 substrate and is not a clinically important inhibitor of tacrolimus metabolism. A meaningful rise in tacrolimus levels is unlikely.
What this interaction means in plain words
Darifenacin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Tacrolimus belongs to Miscellaneous.
Why it happens
Theoretical weak CYP3A4 competition; both are CYP3A4 substrates.
What to do
Continue routine tacrolimus trough monitoring; no empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Darifenacin with Tacrolimus?
MediHelp rates the interaction as minor. Darifenacin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is mainly a CYP3A4 substrate and is not a clinically important inhibitor of tacrolimus metabolism. A meaningful rise in tacrolimus levels is unlikely.
How serious is the interaction between Darifenacin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue routine tacrolimus trough monitoring; no empirical dose change is needed.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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