Drug interactions
Darifenacin + Voriconazole
Severity: Major
Darifenacin and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can substantially raise darifenacin exposure, increasing antimuscarinic adverse effects and potentially QT-related risk. Strong CYP3A4 inhibitors are a labeled concern for darifenacin.
What this interaction means in plain words
Darifenacin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darifenacin belongs to Genitourinary; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces darifenacin clearance.
What to do
Avoid combining where possible, or limit darifenacin to the lowest dose (7.5 mg daily) with monitoring for anticholinergic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Darifenacin
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Darifenacin with Voriconazole?
MediHelp rates the interaction as major. Darifenacin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole inhibits CYP3A4 and can substantially raise darifenacin exposure, increasing antimuscarinic adverse effects and potentially QT-related risk. Strong CYP3A4 inhibitors are a labeled concern for darifenacin.
How serious is the interaction between Darifenacin and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or limit darifenacin to the lowest dose (7.5 mg daily) with monitoring for anticholinergic toxicity.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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