Drug interactions
Darolutamide + Erythromycin
Severity: Moderate
Darolutamide and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits both P-gp and CYP3A4 and may increase darolutamide exposure, raising the risk of adverse effects such as fatigue and rare cardiac events.
What this interaction means in plain words
Darolutamide and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of P-gp and CYP3A4 reduces darolutamide efflux and metabolism.
What to do
Monitor closely for darolutamide adverse reactions and reduce the dose if poorly tolerated. Consider azithromycin as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Erythromycin?
MediHelp rates the interaction as moderate. Darolutamide and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits both P-gp and CYP3A4 and may increase darolutamide exposure, raising the risk of adverse effects such as fatigue and rare cardiac events.
How serious is the interaction between Darolutamide and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for darolutamide adverse reactions and reduce the dose if poorly tolerated. Consider azithromycin as an alternative.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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