Drug interactions
Darolutamide + Fluvastatin
Severity: Moderate
Darolutamide and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits the breast cancer resistance protein (BCRP) efflux transporter, and fluvastatin is a BCRP substrate. Coadministration may raise fluvastatin exposure and increase the risk of statin-related muscle toxicity.
What this interaction means in plain words
Darolutamide and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Fluvastatin belongs to Cardiovascular.
Why it happens
Darolutamide inhibits BCRP, reducing intestinal and hepatic efflux of fluvastatin and increasing its systemic exposure.
What to do
Use the lowest effective fluvastatin dose and monitor for myalgia, weakness or dark urine; check CK if symptoms occur. Consider an alternative statin if muscle symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Fluvastatin?
MediHelp rates the interaction as moderate. Darolutamide and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits the breast cancer resistance protein (BCRP) efflux transporter, and fluvastatin is a BCRP substrate. Coadministration may raise fluvastatin exposure and increase the risk of statin-related muscle toxicity.
How serious is the interaction between Darolutamide and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose and monitor for myalgia, weakness or dark urine; check CK if symptoms occur. Consider an alternative statin if muscle symptoms develop.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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