Drug interactions
Darolutamide + Glyburide-metformin
Severity: Moderate
Darolutamide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits breast cancer resistance protein (BCRP), and glyburide is a BCRP substrate, so its exposure may rise. Higher glyburide levels can increase the risk of hypoglycemia. The effect on metformin is not expected to be clinically important.
What this interaction means in plain words
Darolutamide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
Why it happens
Darolutamide inhibits BCRP-mediated efflux, which may increase glyburide absorption and systemic exposure.
What to do
Monitor blood glucose more frequently when darolutamide is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Darolutamide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits breast cancer resistance protein (BCRP), and glyburide is a BCRP substrate, so its exposure may rise. Higher glyburide levels can increase the risk of hypoglycemia. The effect on metformin is not expected to be clinically important.
How serious is the interaction between Darolutamide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when darolutamide is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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