Drug interactions
Darolutamide + Ketoconazole
Severity: Moderate
Darolutamide and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole inhibits both P-gp and CYP3A4, which are involved in darolutamide disposition, so darolutamide exposure may rise. This may increase adverse effects such as fatigue and other dose-related toxicity.
What this interaction means in plain words
Darolutamide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Ketoconazole belongs to Anti Fungals.
Why it happens
Combined P-gp and CYP3A4 inhibition reduces darolutamide efflux and metabolism.
What to do
Monitor closely for adverse reactions and reduce the darolutamide dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Ketoconazole?
MediHelp rates the interaction as moderate. Darolutamide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole inhibits both P-gp and CYP3A4, which are involved in darolutamide disposition, so darolutamide exposure may rise. This may increase adverse effects such as fatigue and other dose-related toxicity.
How serious is the interaction between Darolutamide and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions and reduce the darolutamide dose if they occur.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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