Drug interactions
Darolutamide + Methadone
Severity: Moderate
Darolutamide and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy can prolong the QT interval, and methadone also prolongs QT in a dose-related manner. Together they raise the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Darolutamide and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; methadone blocks hERG channels and androgen deprivation may prolong repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc periodically and reassess if it rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darolutamide
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Darolutamide with Methadone?
MediHelp rates the interaction as moderate. Darolutamide and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy can prolong the QT interval, and methadone also prolongs QT in a dose-related manner. Together they raise the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
How serious is the interaction between Darolutamide and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc periodically and reassess if it rises markedly.
What other medicines interact with Darolutamide?
MediHelp also lists interactions of Darolutamide with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Darolutamide page.
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