Drug interactions
Darolutamide + Pazopanib
Severity: Moderate
Darolutamide and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, and pazopanib is a BCRP substrate, so pazopanib exposure may rise. The magnitude is uncertain, but higher exposure could increase adverse effects such as hepatotoxicity and hypertension.
What this interaction means in plain words
Darolutamide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux of pazopanib, expected to raise its exposure.
What to do
Monitor liver tests, blood pressure and other adverse effects when starting darolutamide. Consider reducing the pazopanib dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Pazopanib?
MediHelp rates the interaction as moderate. Darolutamide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, and pazopanib is a BCRP substrate, so pazopanib exposure may rise. The magnitude is uncertain, but higher exposure could increase adverse effects such as hepatotoxicity and hypertension.
How serious is the interaction between Darolutamide and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests, blood pressure and other adverse effects when starting darolutamide. Consider reducing the pazopanib dose if toxicity appears.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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