Drug interactions
Darolutamide + Sulphasalazine
Severity: Moderate
Darolutamide and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, and sulfasalazine is a BCRP substrate, so sulfasalazine exposure may increase. This could heighten sulfasalazine adverse effects such as gastrointestinal upset, rash and blood dyscrasias.
What this interaction means in plain words
Darolutamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of the BCRP efflux transporter by darolutamide increases sulfasalazine absorption and systemic exposure.
What to do
Monitor for sulfasalazine adverse effects and check blood counts and liver tests as appropriate. Consider reducing the sulfasalazine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Sulphasalazine?
MediHelp rates the interaction as moderate. Darolutamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, and sulfasalazine is a BCRP substrate, so sulfasalazine exposure may increase. This could heighten sulfasalazine adverse effects such as gastrointestinal upset, rash and blood dyscrasias.
How serious is the interaction between Darolutamide and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects and check blood counts and liver tests as appropriate. Consider reducing the sulfasalazine dose if toxicity occurs.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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