Drug interactions
Darunavir + Dexamethasone-tobramycin
Severity: Moderate
Darunavir and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir inhibits CYP3A4 and may increase dexamethasone exposure, while dexamethasone is a CYP3A4 inducer and may lower darunavir levels. This matters mainly with systemic dexamethasone, and less with topical or ophthalmic use.
What this interaction means in plain words
Darunavir and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Bidirectional CYP3A4 effects: inhibition by darunavir/ritonavir and induction by dexamethasone.
What to do
With systemic dexamethasone, monitor HIV viral load and corticosteroid adverse effects such as Cushingoid features and adrenal suppression. Consider a lower dexamethasone dose or an alternative corticosteroid for prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Darunavir and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted darunavir inhibits CYP3A4 and may increase dexamethasone exposure, while dexamethasone is a CYP3A4 inducer and may lower darunavir levels. This matters mainly with systemic dexamethasone, and less with topical or ophthalmic use.
How serious is the interaction between Darunavir and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor HIV viral load and corticosteroid adverse effects such as Cushingoid features and adrenal suppression. Consider a lower dexamethasone dose or an alternative corticosteroid for prolonged use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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