Drug interactions
Darunavir + Diltiazem
Severity: Major
Darunavir and Diltiazem: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, can markedly raise diltiazem levels, and diltiazem may in turn raise darunavir. This increases the risk of bradycardia, AV block and hypotension.
What this interaction means in plain words
Darunavir and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Diltiazem belongs to Cardiovascular.
Why it happens
Mutual CYP3A4 inhibition, with boosted darunavir regimens producing strong inhibition of diltiazem metabolism.
What to do
Use a reduced diltiazem dose with ECG, heart rate and blood pressure monitoring, or choose an alternative antihypertensive. Watch for darunavir adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Diltiazem?
MediHelp rates the interaction as major. Darunavir and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, can markedly raise diltiazem levels, and diltiazem may in turn raise darunavir. This increases the risk of bradycardia, AV block and hypotension.
How serious is the interaction between Darunavir and Diltiazem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced diltiazem dose with ECG, heart rate and blood pressure monitoring, or choose an alternative antihypertensive. Watch for darunavir adverse effects.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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