Drug interactions
Darunavir + Doxorubicin
Severity: Moderate
Darunavir and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a booster, inhibits CYP3A4 and P-gp and may increase doxorubicin exposure. This could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Darunavir and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Doxorubicin belongs to Oncology.
Why it happens
Darunavir and its pharmacokinetic booster inhibit CYP3A4 and P-gp, decreasing doxorubicin clearance.
What to do
Monitor blood counts and cardiac function closely. Reduce the doxorubicin dose if marked toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Doxorubicin?
MediHelp rates the interaction as moderate. Darunavir and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with a booster, inhibits CYP3A4 and P-gp and may increase doxorubicin exposure. This could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Darunavir and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely. Reduce the doxorubicin dose if marked toxicity occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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