Drug interactions
Darunavir + Empagliflozin-linagliptin
Severity: Moderate
Darunavir and Empagliflozin-linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a pharmacokinetic booster, may raise linagliptin exposure, although linagliptin has a wide safety margin. Protease inhibitors can also worsen insulin resistance and raise blood glucose, which may reduce the glucose-lowering effect of the antidiabetic combination.
What this interaction means in plain words
Darunavir and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Empagliflozin-linagliptin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein (mainly by the booster) increases linagliptin levels, while protease inhibitor-related insulin resistance opposes the antihyperglycemic effect.
What to do
Monitor blood glucose and HbA1c after starting or stopping darunavir and adjust the antidiabetic regimen if control changes. No routine linagliptin dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Darunavir and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with a pharmacokinetic booster, may raise linagliptin exposure, although linagliptin has a wide safety margin. Protease inhibitors can also worsen insulin resistance and raise blood glucose, which may reduce the glucose-lowering effect of the antidiabetic combination.
How serious is the interaction between Darunavir and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping darunavir and adjust the antidiabetic regimen if control changes. No routine linagliptin dose change is needed.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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