Drug interactions
Darunavir + Ethosuximide
Severity: Moderate
Darunavir and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is usually given with a booster such as ritonavir or cobicistat and strongly inhibits CYP3A4. Ethosuximide levels may rise, increasing the risk of dose-related toxicity.
What this interaction means in plain words
Darunavir and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Ethosuximide belongs to Central Nervous System.
Why it happens
Boosted darunavir inhibits CYP3A4 and reduces ethosuximide clearance.
What to do
Monitor for ethosuximide adverse effects and check serum levels when starting or stopping the antiretroviral. Reduce the ethosuximide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Ethosuximide?
MediHelp rates the interaction as moderate. Darunavir and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir is usually given with a booster such as ritonavir or cobicistat and strongly inhibits CYP3A4. Ethosuximide levels may rise, increasing the risk of dose-related toxicity.
How serious is the interaction between Darunavir and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide adverse effects and check serum levels when starting or stopping the antiretroviral. Reduce the ethosuximide dose as needed.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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