Drug interactions
Darunavir + Fluticasone furoate
Severity: Moderate
Darunavir and Fluticasone furoate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, particularly when boosted with ritonavir or cobicistat, raises systemic fluticasone exposure. This can lead to adrenal suppression and Cushing syndrome with prolonged use.
What this interaction means in plain words
Darunavir and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Darunavir (with booster) inhibits CYP3A4, reducing fluticasone clearance.
What to do
Consider switching to beclomethasone for long-term therapy. Otherwise monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Fluticasone furoate?
MediHelp rates the interaction as moderate. Darunavir and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, particularly when boosted with ritonavir or cobicistat, raises systemic fluticasone exposure. This can lead to adrenal suppression and Cushing syndrome with prolonged use.
How serious is the interaction between Darunavir and Fluticasone furoate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider switching to beclomethasone for long-term therapy. Otherwise monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Darunavir?
MediHelp also lists interactions of Darunavir with, for example, Alfuzosin, Avanafil, Dronedarone. The full list is on the Darunavir page.
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