Drug interactions
Darunavir + Glibenclamide
Severity: Moderate
Darunavir and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors, including darunavir, can cause insulin resistance and hyperglycemia, which may reduce glycemic control in patients taking glyburide. Diabetes may worsen or need treatment adjustment after the antiretroviral is started.
What this interaction means in plain words
Darunavir and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Glibenclamide belongs to Endocrine.
Why it happens
Protease inhibitors can induce insulin resistance and impair glucose handling, opposing the effect of glyburide.
What to do
Monitor blood glucose and HbA1c after starting darunavir and increase or modify the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Glibenclamide?
MediHelp rates the interaction as moderate. Darunavir and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors, including darunavir, can cause insulin resistance and hyperglycemia, which may reduce glycemic control in patients taking glyburide. Diabetes may worsen or need treatment adjustment after the antiretroviral is started.
How serious is the interaction between Darunavir and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting darunavir and increase or modify the antidiabetic regimen if control worsens.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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