Drug interactions
Darunavir + Glimepiride-pioglitazone
Severity: Moderate
Darunavir and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effect of antidiabetic drugs. Darunavir is usually boosted with ritonavir or cobicistat, which can also affect drug metabolism.
What this interaction means in plain words
Darunavir and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Protease inhibitors impair insulin sensitivity and glucose uptake, which opposes the effect of glimepiride and pioglitazone.
What to do
Monitor blood glucose and HbA1c during antiretroviral therapy. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Darunavir and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effect of antidiabetic drugs. Darunavir is usually boosted with ritonavir or cobicistat, which can also affect drug metabolism.
How serious is the interaction between Darunavir and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during antiretroviral therapy. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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