Drug interactions
Darunavir + Hydrocortisone
Severity: Moderate
Darunavir and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir inhibits CYP3A4 and can raise corticosteroid exposure, risking Cushing syndrome and adrenal suppression with prolonged use. Hydrocortisone is affected less than other steroids, but the risk remains with long-term therapy.
What this interaction means in plain words
Darunavir and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Hydrocortisone belongs to Endocrine.
Why it happens
Ritonavir or cobicistat boosting with darunavir inhibits CYP3A4, reducing hydrocortisone clearance.
What to do
Monitor for Cushingoid features, hyperglycemia and adrenal suppression with long-term use, and use the lowest effective hydrocortisone dose. For replacement therapy, consider dose adjustment under endocrine guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Hydrocortisone?
MediHelp rates the interaction as moderate. Darunavir and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted darunavir inhibits CYP3A4 and can raise corticosteroid exposure, risking Cushing syndrome and adrenal suppression with prolonged use. Hydrocortisone is affected less than other steroids, but the risk remains with long-term therapy.
How serious is the interaction between Darunavir and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features, hyperglycemia and adrenal suppression with long-term use, and use the lowest effective hydrocortisone dose. For replacement therapy, consider dose adjustment under endocrine guidance.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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