Drug interactions
Darunavir + Insulin detemir
Severity: Moderate
Darunavir and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, boosted protease inhibitor therapy may be linked to insulin resistance and hyperglycemia, potentially reducing insulin effect. The effect is variable.
What this interaction means in plain words
Darunavir and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Insulin detemir belongs to Endocrine.
Why it happens
Protease inhibitors can impair peripheral glucose uptake and insulin sensitivity, antagonizing insulin.
What to do
Monitor blood glucose after starting darunavir. Increase insulin detemir dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darunavir and Insulin detemir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin detemir
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Insulin detemir?
MediHelp rates the interaction as moderate. Darunavir and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, boosted protease inhibitor therapy may be linked to insulin resistance and hyperglycemia, potentially reducing insulin effect. The effect is variable.
How serious is the interaction between Darunavir and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting darunavir. Increase insulin detemir dose if hyperglycemia develops.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
