Drug interactions
Darunavir + Isoniazid
Severity: Minor
Darunavir and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may weakly inhibit CYP3A4, but darunavir is given with a strong booster, so any additional effect is negligible. Both drugs can cause hepatotoxicity.
What this interaction means in plain words
Darunavir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid; additive hepatotoxicity is the main concern.
What to do
No dose change needed. Monitor liver enzymes during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darunavir and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Isoniazid?
MediHelp rates the interaction as minor. Darunavir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may weakly inhibit CYP3A4, but darunavir is given with a strong booster, so any additional effect is negligible. Both drugs can cause hepatotoxicity.
How serious is the interaction between Darunavir and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed. Monitor liver enzymes during combined therapy.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
