Drug interactions
Darunavir + Ketamine
Severity: Moderate
Darunavir and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is normally given with a pharmacokinetic booster (ritonavir or cobicistat) that strongly inhibits CYP3A4, so ketamine exposure is more likely to rise than fall. Greater exposure may prolong sedation and cause more pronounced hemodynamic or psychotomimetic effects. Effects are uncertain and depend on the regimen.
What this interaction means in plain words
Darunavir and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Ketamine belongs to Central Nervous System.
Why it happens
Altered CYP3A4 metabolism of ketamine, mainly inhibition by the boosted regimen.
What to do
Titrate ketamine to clinical effect and monitor sedation depth and vital signs. Expect possible prolonged recovery in patients on boosted darunavir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Ketamine?
MediHelp rates the interaction as moderate. Darunavir and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir is normally given with a pharmacokinetic booster (ritonavir or cobicistat) that strongly inhibits CYP3A4, so ketamine exposure is more likely to rise than fall. Greater exposure may prolong sedation and cause more pronounced hemodynamic or psychotomimetic effects. Effects are uncertain and depend on the regimen.
How serious is the interaction between Darunavir and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical effect and monitor sedation depth and vital signs. Expect possible prolonged recovery in patients on boosted darunavir.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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