Drug interactions
Darunavir + Metformin
Severity: Minor
Darunavir and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can induce insulin resistance and hyperglycemia, potentially reducing the effect of metformin. Darunavir's metabolic effect is generally modest.
What this interaction means in plain words
Darunavir and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Metformin belongs to Endocrine.
Why it happens
Protease inhibitor-associated insulin resistance opposes metformin's glucose-lowering effect.
What to do
Monitor glucose and HbA1c when starting darunavir and titrate metformin as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Metformin?
MediHelp rates the interaction as minor. Darunavir and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Protease inhibitors can induce insulin resistance and hyperglycemia, potentially reducing the effect of metformin. Darunavir's metabolic effect is generally modest.
How serious is the interaction between Darunavir and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when starting darunavir and titrate metformin as needed.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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