Drug interactions
Darunavir + Pitavastatin
Severity: Minor
Darunavir and Pitavastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitavastatin has little CYP3A4 metabolism, and studies of darunavir with ritonavir show no clinically relevant change in pitavastatin exposure. A meaningful interaction is unlikely.
What this interaction means in plain words
Darunavir and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Pitavastatin belongs to Cardiovascular.
Why it happens
Minimal effect; pitavastatin is cleared mainly by hepatic uptake and glucuronidation rather than CYP3A4.
What to do
No dose adjustment is generally needed. Monitor for muscle symptoms as for routine statin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pitavastatin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Pitavastatin?
MediHelp rates the interaction as minor. Darunavir and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pitavastatin has little CYP3A4 metabolism, and studies of darunavir with ritonavir show no clinically relevant change in pitavastatin exposure. A meaningful interaction is unlikely.
How serious is the interaction between Darunavir and Pitavastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for muscle symptoms as for routine statin therapy.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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