Drug interactions
Darunavir + Rabeprazole
Severity: Minor
Darunavir and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4, which could modestly raise rabeprazole levels. Rabeprazole has a wide safety margin and is cleared largely non-enzymatically, so the effect is generally unimportant.
What this interaction means in plain words
Darunavir and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition by darunavir and its booster slightly reduces rabeprazole metabolism.
What to do
No dose adjustment is typically required; monitor for PPI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Rabeprazole?
MediHelp rates the interaction as minor. Darunavir and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4, which could modestly raise rabeprazole levels. Rabeprazole has a wide safety margin and is cleared largely non-enzymatically, so the effect is generally unimportant.
How serious is the interaction between Darunavir and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is typically required; monitor for PPI adverse effects.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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