Drug interactions
Darunavir + Theophylline
Severity: Moderate
Darunavir and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, may raise theophylline levels via CYP3A4 inhibition. Ritonavir can also induce CYP1A2 and lower levels, so the net effect is unpredictable. Either toxicity or loss of efficacy may occur.
What this interaction means in plain words
Darunavir and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Theophylline belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 by darunavir and its boosters, with possible CYP1A2 induction by ritonavir, alters theophylline clearance.
What to do
Monitor theophylline serum concentrations when starting or stopping darunavir regimens and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Theophylline?
MediHelp rates the interaction as moderate. Darunavir and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, may raise theophylline levels via CYP3A4 inhibition. Ritonavir can also induce CYP1A2 and lower levels, so the net effect is unpredictable. Either toxicity or loss of efficacy may occur.
How serious is the interaction between Darunavir and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum concentrations when starting or stopping darunavir regimens and adjust the dose.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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