Drug interactions
Darunavir + Zolpidem
Severity: Minor
Darunavir and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a booster, inhibits CYP3A4 and may raise zolpidem levels. This may lead to increased sedation and psychomotor impairment.
What this interaction means in plain words
Darunavir and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Zolpidem belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated zolpidem metabolism by darunavir and its pharmacokinetic booster.
What to do
Begin with a low zolpidem dose and monitor for excessive sedation or next-day impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Zolpidem?
MediHelp rates the interaction as minor. Darunavir and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually given with a booster, inhibits CYP3A4 and may raise zolpidem levels. This may lead to increased sedation and psychomotor impairment.
How serious is the interaction between Darunavir and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with a low zolpidem dose and monitor for excessive sedation or next-day impairment.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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