Drug interactions
Dasatinib + Deferasirox
Severity: Moderate
Dasatinib and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and may lower dasatinib exposure, possibly reducing efficacy. Both drugs may also affect blood counts and renal function.
What this interaction means in plain words
Dasatinib and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Deferasirox belongs to Miscellaneous.
Why it happens
CYP3A4 induction by deferasirox increases dasatinib metabolism.
What to do
Monitor leukemia response and consider dasatinib dose adjustment if response is lost. Monitor renal function and blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Dasatinib with Deferasirox?
MediHelp rates the interaction as moderate. Dasatinib and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and may lower dasatinib exposure, possibly reducing efficacy. Both drugs may also affect blood counts and renal function.
How serious is the interaction between Dasatinib and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor leukemia response and consider dasatinib dose adjustment if response is lost. Monitor renal function and blood counts.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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