Drug interactions
Dasatinib + Dexamethasone-tobramycin
Severity: Moderate
Dasatinib and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower dasatinib exposure, potentially reducing its efficacy. Dasatinib is a weak CYP3A4 inhibitor and may slightly raise dexamethasone exposure.
What this interaction means in plain words
Dasatinib and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by dexamethasone increases dasatinib clearance, with weak reciprocal inhibition.
What to do
Monitor leukemia response when systemic dexamethasone is given with dasatinib. Consider an alternative to dexamethasone if reduced efficacy is suspected, or increase dasatinib dose with monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Dasatinib and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce CYP3A4 and lower dasatinib exposure, potentially reducing its efficacy. Dasatinib is a weak CYP3A4 inhibitor and may slightly raise dexamethasone exposure.
How serious is the interaction between Dasatinib and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor leukemia response when systemic dexamethasone is given with dasatinib. Consider an alternative to dexamethasone if reduced efficacy is suspected, or increase dasatinib dose with monitoring.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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