Drug interactions
Dasatinib + Dichlorphenamide
Severity: Moderate
Dasatinib and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide can cause hypokalemia, and dasatinib can prolong the QT interval. Low potassium increases the risk of QT-related arrhythmias.
What this interaction means in plain words
Dasatinib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive effect: carbonic anhydrase inhibitor-induced potassium loss potentiates dasatinib QT prolongation.
What to do
Monitor serum potassium and magnesium regularly and replace as needed. Check ECG if electrolytes are abnormal or other QT-prolonging drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dasatinib with Dichlorphenamide?
MediHelp rates the interaction as moderate. Dasatinib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide can cause hypokalemia, and dasatinib can prolong the QT interval. Low potassium increases the risk of QT-related arrhythmias.
How serious is the interaction between Dasatinib and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace as needed. Check ECG if electrolytes are abnormal or other QT-prolonging drugs are used.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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