Drug interactions
Dasatinib + Diltiazem
Severity: Moderate
Dasatinib and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase dasatinib exposure, raising the risk of myelosuppression, fluid retention and QT prolongation.
What this interaction means in plain words
Dasatinib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4, the main metabolic pathway of dasatinib.
What to do
Prefer a non-inhibiting alternative; otherwise monitor blood counts, ECG and toxicity, and reduce the dasatinib dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Diltiazem?
MediHelp rates the interaction as moderate. Dasatinib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase dasatinib exposure, raising the risk of myelosuppression, fluid retention and QT prolongation.
How serious is the interaction between Dasatinib and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inhibiting alternative; otherwise monitor blood counts, ECG and toxicity, and reduce the dasatinib dose if needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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