Drug interactions
Dasatinib + Doxorubicin liposomal
Severity: Moderate
Dasatinib and Doxorubicin liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is partly handled by CYP3A4 and P-glycoprotein, but the liposomal form has altered kinetics, so the effect of dasatinib is uncertain and likely small. Both agents have cardiac and hematologic toxicity.
What this interaction means in plain words
Dasatinib and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible weak CYP3A4/P-gp inhibition by dasatinib; additive toxicities.
What to do
Monitor blood counts and cardiac function, including left ventricular ejection fraction as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Doxorubicin liposomal?
MediHelp rates the interaction as moderate. Dasatinib and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxorubicin is partly handled by CYP3A4 and P-glycoprotein, but the liposomal form has altered kinetics, so the effect of dasatinib is uncertain and likely small. Both agents have cardiac and hematologic toxicity.
How serious is the interaction between Dasatinib and Doxorubicin liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, including left ventricular ejection fraction as clinically indicated.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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