Drug interactions
Dasatinib + Doxorubicin
Severity: Minor
Dasatinib and Doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor, but CYP3A4 is a minor pathway for doxorubicin. A clinically meaningful rise in doxorubicin levels is not expected, though overlapping myelosuppression and cardiac effects of the two drugs are possible.
What this interaction means in plain words
Dasatinib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Doxorubicin belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by dasatinib, with a minor effect on doxorubicin metabolism.
What to do
No dose change is routinely needed; monitor blood counts and cardiac function as part of standard anthracycline care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Doxorubicin?
MediHelp rates the interaction as minor. Dasatinib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor, but CYP3A4 is a minor pathway for doxorubicin. A clinically meaningful rise in doxorubicin levels is not expected, though overlapping myelosuppression and cardiac effects of the two drugs are possible.
How serious is the interaction between Dasatinib and Doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor blood counts and cardiac function as part of standard anthracycline care.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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