Drug interactions
Dasatinib + Ethinyl estradiol-levonorgestrel
Severity: Minor
Dasatinib and Ethinyl estradiol-levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and could modestly increase dasatinib exposure. Any increase is likely small, but dasatinib toxicities such as myelosuppression, fluid retention and QT prolongation are dose-related.
What this interaction means in plain words
Dasatinib and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated dasatinib metabolism by ethinyl estradiol.
What to do
No dose adjustment is usually needed; monitor blood counts and for fluid retention during therapy. Note that dasatinib is teratogenic and contraception is important.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as minor. Dasatinib and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A4 inhibitor and could modestly increase dasatinib exposure. Any increase is likely small, but dasatinib toxicities such as myelosuppression, fluid retention and QT prolongation are dose-related.
How serious is the interaction between Dasatinib and Ethinyl estradiol-levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor blood counts and for fluid retention during therapy. Note that dasatinib is teratogenic and contraception is important.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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